New York Times: Artemisinin Resistance
January 27th, 2009 | Posted by emilyThe front page of nytimes.com today includes an article called, “Spread of Malaria Feared as Drug Loses Potency”, describing a recent study in the New England Journal of Medicine that shows some resistance to artemisinin in Cambodia. Read the article here.
The signs of resistance to artemisinin—a drug extracted from a Chinese herb to treat malaria—are certainly troubling. The best anti-malarial medicines are made using artemisinin and it would be a major blow to the global health community if it was rendered ineffective. Any indications of resistance should and must be closely monitored and contained.
It’s important to note, however, that this resistance occurred in the face of artemisinin alone. The most recent and most effective drugs to treat malaria are artemisinin-based combination therapies (ACTs) which combine more than one drug with artemisinin to stay ahead of resistance. And the two people in the study who had build up a resistance to artemisinin were eventually cured.
That’s not to say this isn’t significant. This resistance was found in Cambodia, the same area which seems to have been a starting point for resistance to chloroquine, one of the first anti-malarials that is now largely ineffective. This shows that even more attention must be paid to intervention tools that will help to prevent malaria, while science continues its efforts to reaffirm the efficacy of malaria treatment like ACTs and build toward a vaccine.
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